It is a specialized technique used in the formulations of the liquidized bed granulation. This distinctive method converts the powder into small, spheroid balls known as granules. These granules are an essential substance as they are used to prepare different dosage forms of medicines such as tablet and capsule. And you need to have the right ingredients and the right forms when we make medicines, and granules are crucial to that.
There are two main parts of fluidized bed granulation process that act in conjunction to each other which include a fluidized bed and a spray system. The fluidized bed is a container which is filled with air or gas. The air or gas then forces its way through the powder to cause it to move and behave like a liquid. This allows for improved mixing of the powder and agglomeration to form granules. In the spray system, a special liquid called a binder is added to the powder.
Adding the liquid binder to the powder forms small bridges between the powder pieces, helping to bond the powder. As air keeps passing through the mixture, those small connections can rupture and small granules start to form. Then, as we continue to add more of the liquid binder, these granules can grow larger until they are the perfect size we want for making medicines.
Fluidized bed granulators are excellent machines that produce uniform granule size, shape, and density. This matters because when the granules are uniform, they facilitate the uniform final product, such has medication, performs its best for those taking it. It does so by precisely regulating three main aspects of the process: airflow, temperature, and the amount of liquid binder that is deposited.
The fluidized bed facilitates the uniform distribution of the liquid binder throughout the powder to produce uniform granules. And every granules is similar to others, which matter a big deal for them. With the spray system, we can control the amount of liquid binder we add, and determine the right size and right shape of the granules you need for effective medicine.
Advantages of using a fluidized bed dryer manufacturer in medicine manufacturing. These granules are high-quality, which in turn results in better final products. The uniform size and shape of the granules ensure effective action of the medicine inside the body. This enables the medicine to be more effective for patients.
Airflow is also very essential in the fluidized bed granulation process. Fluidization of the powder is determined by the quantity of gas passing through the powder bed. If there is excessive gas, however, some powder can be blown or carried away. But if there’s too little, the powder sticks together and makes large clumps known as agglomerates. This is not ideal for granule production.
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